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pentobarbital raises toxicity of methoxyflurane by raising metabolism. Contraindicated. Enhanced metabolism of methoxyflurane to nephrotoxic compounds.
pentobarbital will reduce the level or outcome of cobimetinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Avoid coadministration. Solid or reasonable CYP3A inducers may possibly lower cobimetinib systemic publicity by >80% and cut down its efficacy.
fentanyl intranasal and pentobarbital equally boost sedation. Steer clear of or Use Alternate Drug. Restrict use to sufferers for whom substitute therapy options are insufficient
Remark: Barbiturates could enhance adverse results, including respiratory despair, produced by toxic doses of TCAs. With therapeutic doses of TCAs, barbiturates boost metabolism and reduce blood concentrations of TCAs.
pentobarbital will lower the extent or impact of quinine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Small/Importance Unidentified.
pentobarbital decreases amounts of ponatinib by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Stay away from Unless of course the coadministration outweighs the doable hazard of ponatinib underexposure; monitor for indications of reduced efficacy.
pentobarbital will boost the amount or influence of ivosidenib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Keep away from or Use Alternate Drug. Coadministration of ivosidenib with sturdy CYP3A4 inducers lowered ivosidenib plasma concentrations.
pentobarbital will lower the extent or outcome of budesonide by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Observe.
Contraindicated. Coadministration of lorlatinib with robust CYP3A inducers is contraindicated. Discontinue the robust CYP3A inducer for three plasma half-life in advance of initiating lorlatinib.
Observe Closely (1)pentobarbital will boost the amount or effect of clopidogrel by influencing more info hepatic/intestinal enzyme CYP3A4 metabolism.
benzhydrocodone/acetaminophen and pentobarbital each increase sedation. Steer clear of or Use Alternate Drug. Limit use to clients for whom alternative cure choices are insufficient
pentobarbital will decrease the extent or effect of suvorexant by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Watch. Robust CYP3A4 inducers may lower suvorexant efficacy; if elevated suvorexant dose expected, usually do not exceed twenty mg/day
pentobarbital will minimize the extent or outcome of almotriptan by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor.